9) Sickle Cell Anemia
Sickle Cell Anemia is a genetic blood disorder. Normally the Red Blood Corpuscles (RBCs) are spherical in shape, their genesis is in bone marrow and their life span is 120 days after which they are destroyed in spleen. But in this condition, RBCs are reduced to crescent shape thus reducing the hemoglobin content and subsequently decreasing the oxygen carrying capacity to different parts of the body. Sickle shaped RBCs stick over the walls of the blood vessels and obliterates the inner circumference of the blood vessels which results in deficit supply of nutrients and oxygen to body tissues. So pain and tiredness are major symptoms associated with permanent damage to heart, brain, lungs and spleen. This condition is related to hemoglobin mutation due to malaria though it has to be proved cent per cent. People in tropical countries like Africa are said to be more prone to Sickle Cell Anemia.